sildenafil 20 mg for erectile dysfunction

Fezolinetant AUC and peak plasma concentration are increased if coadministered with drugs that are weak, moderate, or strong CYP1A2 inhibitors. Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Your doctor may adjust your dose if needed. Use Caution/Monitor. phenytoin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. atenolol increases effects of sildenafil by additive vasodilation. Can Women Take Viagra (Sildenafil) for Low Libido? - Verywell Health Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. Avoid or Use Alternate Drug. Monitor Closely (1)carbamazepine will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Patients will use daily tadalafil 5 mg or daily sildenafil 25 mg 4. Use Caution/Monitor. Monitor Closely (1)amobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension; do not administer within 24 hr of each other. Monitor Closely (1)duvelisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, decrease in amount of urine or the frequency of urination, dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position, dryness, redness, scaling, or peeling of the skin, redness, burning, or swelling of the eyes, seeing shades of colors differently than before, swelling of the face, hands, feet, or lower legs, unusual feeling of burning or stinging of the skin, pain or tenderness around the eyes and cheekbones, diarrhea or stomach cramps (severe or continuing), numbness or tingling of the hands, legs, or feet, redness, soreness, swelling, or bleeding of the gums, sensation of motion, usually whirling, either of one's self or of one's surroundings, sexual problems in men (continuing), including failure to experience a sexual orgasm. nitroprusside sodium, sildenafil. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Serious - Use Alternative (1)amyl nitrite, sildenafil. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. sildenafil, benazepril. Multiple myeloma (blood related cancer) or. Use Caution/Monitor. Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate. Benefits of Taking Viagra Daily - Healthline Serious - Use Alternative (1)sildenafil increases effects of silodosin by pharmacodynamic synergism. Use Caution/Monitor. Use only the brand of this medicine that your doctor prescribed. verapamil will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. It works by dilating blood vessels and increasing blood flow to certain areas of the body. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Minor/Significance Unknown. Use Caution/Monitor. sapropterin, sildenafil. Avoid or Use Alternate Drug. Uses Before taking Warnings Side effects Overdose Dosage FAQ Uses of Sildenafil Tablets: aprepitant will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor blood pressure. Either increases effects of the other by pharmacodynamic synergism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Serious - Use Alternative (1)abametapir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Sildenafil in the Treatment of Raynaud's Phenomenon Resistant to nafcillin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. sildenafil increases effects of labetalol by pharmacodynamic synergism. enzalutamide will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by additive vasodilation. commonly, these are "preferred" (on formulary) brand drugs. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Monitor Closely (1)sildenafil, tamsulosin. In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Coadministration with strong CYP3A4 inhibitors and sildenafil (for pulmonary arterial hypertension) is not recommended. nelfinavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. sildenafil increases effects of phenoxybenzamine by pharmacodynamic synergism. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. The recommended dosage for tablet and oral suspension formularies is 5 mg or 20 mg three times daily, 4 to 6 hours apart. Contraindicated. Monitor Closely (1)grapefruit will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Published In Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Use Caution/Monitor. If not feasible, avoid use of abametapir. Modify Therapy/Monitor Closely. Erectile dysfunction: Viagra and other oral medications erythromycin stearate will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Its effects often last for 4 to 5 hours. Contraindicated. Sildenafil is used to treat men who have erectile dysfunction (also called sexual impotence). Share cases and questions with Physicians on Medscape consult. 20 Mg Sildenafil Enough For Erectile Dysfunction - NHERI Lehigh RTMD Use Caution/Monitor. If unavoidable, reduce CYP3A substrate dose according to product labeling. . Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Liver disease, severeUse with caution. armodafinil will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Refer to the prescribing information of PDE5 inhibitors for dose recommendations. Posted on 2023-06-28 2023-06-28 by ceac-admin. Serious - Use Alternative (1)levoketoconazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. efavirenz will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. epoprostenol increases effects of sildenafil by additive vasodilation. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Sildenafil Dosage Guide + Max Dose, Adjustments - Drugs.com eslicarbazepine acetate will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. carvedilol increases effects of sildenafil by additive vasodilation. Serious - Use Alternative (1)mifepristone will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. Ask your healthcare professional how you should dispose of any medicine you do not use. It might work longer if you have mild to moderate erectile dysfunction. Monitor Closely (1)miconazole vaginal will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The strengths of generic Viagra drugs are 25, 50 and 100 mg. secobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Throw away any unused mixed Revatio oral liquid after 60 days. Contraindicated (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. PDE-5 blockers also relax blood vessels in other parts of the body to increase blood flow, which is why they are also used for erectile dysfunction. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. propranolol increases effects of sildenafil by additive vasodilation. Coadministration with strong CYP3A4 inhibitors and sildenafil (for pulmonary arterial hypertension) is not recommended. PRECAUTIONS: Before taking sildenafil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Sildenafil: Usage, Dosage & Side Effects - Drugs.com Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Use Caution/Monitor. Viagra also contains sildenafil. Avoid or Use Alternate Drug. Contact the applicable plan More About Sildenafil Follow your doctor's orders or the directions on the label. Contraindicated. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Erythromycin (Systemic): May increase the serum concentration of Sildenafil. Contraindicated. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Mechanism: additive vasodilation. Possible additive vasorelaxation, leading to low blood pressure. Avoid or Use Alternate Drug. When used for erectile dysfunction, consider reducing initial sildenafil dose of 25 mg in patients also taking a strong CYP3A4 inhibitor and monitor for sildenafil toxicities (eg, dyspepsia, headache, hypotension). If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling. Contraindicated. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Your doctor may start treatment with a lower dose of sildenafil to minimize your risk of low blood pressure.Other medications can affect the removal of sildenafil from your body, which may affect how sildenafil works. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. bisoprolol increases effects of sildenafil by additive vasodilation. Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. erythromycin lactobionate will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)lonafarnib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil (Oral Tablet): Side Effects, Dosage, Uses, and Review Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Monitor Closely (1)griseofulvin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Tell your doctor if your condition does not improve. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events; contraindication applies to chronic administration of sildenafil for PAH; for ED, not to exceed 25 mg in 48 hr. Monitor Closely (1)idelalisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. When you're ready to get to "business," you take sildenafil, which in an appropriate dosage will prepare you for better action for the next few hours, according to the National Library of Medicine. When hypertension occurs in the lungs, the heart must work harder to pump enough blood through the lungs. This will increase the supply of blood to the lungs and reduce the workload of the heart. Sildenafil is an effective oral treatment in men with erectile dysfunction. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Reduce sildenafil dose if used for erectile dysfunction. lorlatinib will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil | Drugs | BNF | NICE If you already use medicine for high blood pressure (hypertension), sildenafil could make your blood pressure go too low. Stomach ulcer, or history of orChance of problems occurring may be increased. Use Caution/Monitor. Stroke (within the last 6 months)Should not be used in patients with these conditions. Adult Initially 50 mg, to be taken approximately 1 hour before sexual activity, adjusted according to response to 25-100 mg (max. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Contraindicated. Avoid or Use Alternate Drug. Sildenafil ist ein PDE-5-Hemmer und unter anderem in Viagra enthalten. Besides its established effect in erectile dysfunction, 4,5 sildenafil provides cGMP-dependent microvascular and . Never use combination with chronic sildenafil for PAH. Sildenafil is a prescription drug. Enhanced hypotensive effects. Avoid or Use Alternate Drug. Sildenafil has an average rating of 8.2 out of 10 from a total of 392 reviews for the treatment of Erectile Dysfunction. ivosidenib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. stiripentol, sildenafil. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Your doctor may adjust your dose as needed and tolerated. Serious - Use Alternative (1)tucatinib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. This drug is available at a middle level co-pay. Use Caution/Monitor. You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke.Rarely, a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, may occur. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Serious - Use Alternative (1)crizotinib increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. nirmatrelvir/ritonavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Can I Take 200 Mg Of Sildenafil she is willing to endure for the harmony of the Chi family. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Potentially fatal hypotension. Tecovirimat is a weak CYP3A4 inducer. Use Caution/Monitor. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. Use Caution/Monitor. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Avoid or Use Alternate Drug. Serious - Use Alternative (1)fexinidazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. abametapir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels, Monitor Closely (1)rifapentine will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. The recommended dosage for tablet and oral suspension formularies is 5 mg or 20 mg three times daily, 4 to 6 hours apart. What is Viagra? Patients who take Liqrev should not take Viagra or any other PDE-5 inhibitors. Avoid or Use Alternate Drug. If you will be taking this medicine for pulmonary arterial hypertension, your doctor will want to check your progress at regular visits. Serious - Use Alternative (1)primidone will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid use of strong CYP3A4 inhibitors. Use Caution/Monitor. nitroglycerin transdermal, sildenafil. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Call your doctor right away if you have blurred vision, confusion, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly, sweating, or unusual tiredness or weakness. The penis is one of the areas where this enzyme works. Use Caution/Monitor. Use Caution/Monitor. Rationale: Erectile dysfunction (ED) is common in middle-aged and elderly men, affecting more than 100 million males worldwide. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Use Caution/Monitor. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Sildenafil (Viagra). commonly, these are generic drugs. Monitor Closely (1)cyclosporine will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Its major appeal? Avoid or Use Alternate Drug. Jiang Shulan smiled mischievously . Last updated on Dec 1, 2022. Monitor Closely (1)voriconazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of sildenafil with strong CYP3A4 inhibitors is not recommended. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Use Caution/Monitor. Monitor Closely (1)erythromycin base will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. Avoid or Use Alternate Drug. Sildenafil User Reviews for Erectile Dysfunction - Drugs.com . Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels, pentobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://www.mayoclinic.org/drugs-supplements/sildenafil-oral-route/proper-use/DRG-20066989, Advertising and sponsorship opportunities. Mechanism: additive vasodilation. Monitor Closely (1)darunavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. ribociclib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Additive hypotensive effects. Monitor Closely (1)cimetidine will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)pentobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Seit rund 20 Jahren wird der Wirkstoff hauptschlich zur Behandlung der erektilen Dysfunktion verordnet. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels, Serious - Use Alternative (1)phenobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil Oral: Uses, Side Effects, Interactions, Pictures - WebMD Applies to the following strengths: 10 mg/mL; 10 mg/12.5 mL; 20 mg; 25 mg; 50 mg; 100 mg Usual Adult Dose for: Erectile Dysfunction Pulmonary Hypertension Usual Geriatric Dose for: Erectile Dysfunction Additional dosage information: Renal Dose Adjustments Liver Dose Adjustments Dose Adjustments Precautions Dialysis Use of Sildenafil (Viagra) in Patients With Cardiovascular Disease Coadministration of these phosphodiesterase inhibitors with clarithromycin, a CYP3A4 inhibitor is not recommended. nilotinib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Modify Therapy/Monitor Closely. Remove the cap by pushing it down and twisting it counter-clockwise. 20 mg Tablet (Viagra) 25 mg 50 mg 100 mg Injectable solution (Revatio) 10 mg/12.5mL Oral suspension (Revatio) 10 mg/12.5mL (when reconstituted) Dosage Considerations - Should be Given as Follows: Erectile Dysfunction Viagra 50 mg orally 1 hour before sexual activity It is not known if the medicine is safe for use in these patients. Compare formulary status to other drugs in the same class. However the dose is usually not more than 40 mg 3 times a day. The treatment of erectile dysfunction in patients with neurogenic Sildenafil 20 mg: Is It the Right Dose for ED? | hims Avoid or Use Alternate Drug. . Indicated for erectile dysfunction 50 mg PO ~1 hr before sexual activity; however, may be taken anywhere from 30 min to 4 hr before sexual activity Maximum dosing frequency is once per day. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Serious - Use Alternative (1)sildenafil increases effects of terazosin by pharmacodynamic synergism. cimetidine will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Crowded disc or low cup to disc ratio in the eye (an eye disorder) or, Hyperlipidemia (high fats in the blood) or, Non-arteritic anterior ischemic optic neuropathy or NAION (serious eye condition), history of or. When used chronically for PAH, sildenafil is contraindicated for use with cobicistat; if used for erectile dysfunction, do not exceed sildenafil 25 mg q48hr. Serious - Use Alternative (1)ivosidenib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Here we report an atypical ED case with no clear manifestation fitting the diagnosis for recognized types of ED. Minor/Significance Unknown. This condition may require prompt medical treatment to prevent serious and permanent damage to your penis. zafirlukast will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Warnings Not recommended during and 2 weeks after itraconazole treatment when sildenafil is used for pulmonary arterial hypertension. iloperidone increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated (1)sildenafil, vericiguat. Monitor Closely (1)fosphenytoin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Should you take a daily erectile dysfunction pill? - Harvard Health affecting hepatic/intestinal enzyme CYP3A4 metabolism. Patient taking sildenafil for PAH with ritonavir is not recommended. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection. Fexinidazole inhibits CYP3A4. Contraindicated. lenacapavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lapatinib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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